Entrepreneurship Ecosystems in Action: Regional Models for Innovation and Economic Transformation
DOI:
https://doi.org/10.55737/rl.2025.43099Keywords:
Entrepreneurial Ecosystems, Innovation Capacity, Regional Economic Transformation, Moderate Mediation, Policy Support & ClustersAbstract
Entrepreneurial ecosystems have emerged as a critical framework for explaining how regions foster innovation and achieve long-term economic transformation. While prior research highlights the importance of ecosystem elements such as finance, networks, and institutions, the pathways through which these systems generate macroeconomic outcomes remain contested, particularly in relation to institutional and policy contexts. This study develops and tests a moderated mediation model linking entrepreneurial ecosystems, innovation capacity, and regional economic transformation, with regional models, policies, and clusters as moderators. Data was collected from 200 ecosystem stakeholders, including entrepreneurs, incubator managers, executives, and policymakers, and analyzed using structural equation modeling with bootstrapped moderated mediation techniques. Results indicate that ecosystem quality significantly enhances innovation capacity and directly contributes to regional transformation. However, the mediating role of innovation capacity was weaker than anticipated and became significant only under high levels of supportive policy and cluster frameworks. These findings advance theory by demonstrating that ecosystems exert both direct effects on regional development and conditional indirect effects through innovation, thereby integrating ecosystem, innovation, and institutional perspectives. Practically, the study underscores the need for policymakers to invest not only in ecosystem infrastructure and networks but also in inclusive and coherent policy frameworks that enable innovation to translate into economic impact. The paper concludes by identifying limitations of the cross-sectional design and outlining avenues for future research on longitudinal ecosystem dynamics and contextual heterogeneity.
References
Acs, Z. J., Braunerhjelm, P., Audretsch, D. B., & Carlsson, B. (2009). The knowledge spillover theory of entrepreneurship. Small Business Economics, 32(1), 15–30. https://doi.org/10.1007/s11187-008-9157-3
Adam, & Farank. (2024). What Does Entrepreneurship Do For Job Creation? | Economic Impact Catalyst. https://www.economicimpactcatalyst.com/blog/entrepreneurship-job-creation
Alabi, M. (2024). Innovation Ecosystems and Collaborative Networks: Fostering Innovation Through Partnerships and Open Innovation.
Aleven, V., McLaughlin, E. A., Glenn, R. A., & Koedinger, K. R. (2016). Instruction based on adaptive learning technologies. Handbook of Research on Learning and Instruction, 2, 522–560.
Alvedalen, J., & Boschma, R. (2017). A critical review of entrepreneurial ecosystems research: Towards a future research agenda. European Planning Studies, 25(6), 887–903. https://doi.org/10.1080/09654313.2017.1299694
Audretsch, D. B., & Belitski, M. (2017). Entrepreneurial ecosystems in cities: Establishing the framework conditions. The Journal of Technology Transfer, 42, 1030–1051. https://doi.org/10.1007/s10961-016-9473-8
Aljarwan, A. A., Yahya, B. A., Almarzooqi, B. M., & Mezher, T. (2019). Examining the framework of entrepreneurial ecosystems: A case study on the United Arab Emirates. International Journal of Entrepreneurship, 23(3). https://khazna.ku.ac.ae/en/publications/examining-the-framework-of-entrepreneurial-ecosystems-a-case-stud
Audretsch, D. B., Cunningham, J. A., Kuratko, D. F., Lehmann, E. E., & Menter, M. (2019). Entrepreneurial ecosystems: economic, technological, and societal impacts. The Journal of technology transfer, 44(2), 313-325. https://doi.org/10.1007/s10961-018-9690-4
Baskin, K. (2019, November 21). Building an Entrepreneurial Ecosystem Babson Thought & Action. Babson Thought & Action.
Beck, D., Pal, A., Zaveri, P., Zheng, A., Tiwari, A. K., & Majumdar, S. (2025). Ecosystem Resilience for Climate Resilience, Strategies and Innovations: A Case Study from Developing Countries. In Sustainable Synergy: Harnessing Ecosystems for Climate Resilience (pp. 49-64). Cham: Springer Nature Switzerland. https://doi.org/10.1007/978-3-031-77957-2_4
Bejjani, M., Göcke, L., & Menter, M. (2023). Digital entrepreneurial ecosystems: A systematic literature review. Technological Forecasting and Social Change, 189, 122372. https://doi.org/10.1016/j.techfore.2023.122372
Bläse, R., Filser, M., Weise, J., Björck, A., & Puumalainen, K. (2025). Identifying institutional gaps: Implications for an early‐stage support framework for impact entrepreneurs. Corporate Social Responsibility and Environmental Management, 32(1), 679–697. https://doi.org/10.1002/csr.2939
Brush, C., Greene, P., Balachandra, L., & Davis, A. (2018). The gender gap in venture capital-progress, problems, and perspectives. Venture Capital, 20(2), 115–136. https://doi.org/10.1080/13691066.2017.1349266
Challoumis, C. (2024). The Economic Ripple Effect-AI’s Role In Shaping The Future Of Work And Wealth. 206–241.
Crotti, R., Potter, J., Shah, P., & Stam, E. (2025). Data and methods for entrepreneurial ecosystem diagnostics (69th ed., OECD SME and Entrepreneurship Papers) [OECD SME and Entrepreneurship Papers]. https://doi.org/10.1787/5173f4a2-en
Dakos, V., Matthews, B., Hendry, A. P., Levine, J., Loeuille, N., Norberg, J., Nosil, P., Scheffer, M., & De Meester, L. (2019). Ecosystem tipping points in an evolving world. Nature Ecology & Evolution, 3(3), 355–362. https://doi.org/10.1038/s41559-019-0797-2
Etzkowitz, H., & Zhou, C. (2017). The triple helix: University–industry–government innovation and entrepreneurship. Routledge.
Ewing, Kauffman, & Marion. (2014, September 24). The Importance of Young Firms for Economic Growth. Kauffman Foundation. https://www.kauffman.org/resources/entrepreneurship-policy-digest/the-importance-of-young-firms-for-economic-growth/
F. Dieffenbacher, S. (2024, January 10). Innovation Ecosystem Guide for Successful Innovation Strategy. Digital Leadership. https://digitalleadership.com/blog/innovation-ecosystem-everything-you-need-to-know-about-it/
Florêncio da Costa, J., Macedo e Silva Calazans, D. L., Vieira de Andrade, A. P., & Galdino de Araújo, A. (2024). INTERNATIONALIZATION ECOSYSTEMS: A FRAMEWORK PROPOSAL FOR THE INTERNATIONAL BUSINESS THEORY. Internext: Revista Electrônica de Negócios Internacionais Da ESPM, 19(2). https://doi.org/10.18568/internext.v19i2.787
GEM. (2024). GEM Global Entrepreneurship Monitor. GEM Global Entrepreneurship Monitor. https://www.gemconsortium.org/report/global-entrepreneurship-monitor-gem-20232024-global-report-25-years-and-growing
Giz, G. (2018). Guide for mapping the entrepreneurial ecosystem: Observe–analyse–visualise. Frankfurt: Deutsche Gesellschaft Für Internationale Zusammenarbeit (GIZ) GmbH.
Gleeson, B. (2025, January 15). Entrepreneurial Ecosystems: Visionary Leadership Meets Economic Growth. Forbes. https://www.forbes.com/sites/brentgleeson/2025/01/15/entrepreneurial-ecosystems-visionary-leadership-meets-economic-growth/
Goletsis, Y., Christogeorgou, K., & Mylonidis, N. (2025). Exploring the effect of institutions on entrepreneurial ecosystems: A meta–analysis. Journal of Small Business Management, 63(3), 936–984. https://doi.org/10.1080/00472778.2024.2363845
Gomes, S., Ferreira, J. J., & Lopes, J. M. (2023a). Entrepreneurial conditions and economic growth in entrepreneurial ecosystems: Evidence from OECD countries. The International Journal of Entrepreneurship and Innovation, 14657503231156340. https://doi.org/10.1177/14657503231156340
Griddlo. (2024, June 7). Equitable Entrepreneurial Ecosystems: Lessons from the Field. Accelerator for America. https://www.acceleratorforamerica.org/news/equitable-entrepreneurial-ecosystems-lessons-from-the-field/
Hajli, N., Baydarova, I., & Nisar, T. (2025). Digital entrepreneurial ecosystem: The role of the sharing economy in driving innovation. Entrepreneurship & Regional Development, 37(5–6), 785–815. https://doi.org/10.1080/08985626.2024.2444908
Harris, J., & Grey, S. (2012). Assessing regional innovative entrepreneurship ecosystems with the global entrepreneurship and development index: the case of scotland. https://www.enterpriseresearch.ac.uk/wp-content/uploads/2014/03/REAPScotlandGEMconfV13-Autio.pdf
Holling, C. S. (1973). Resilience and stability of ecological systems.
Hou, H., & Ma, H. (2025). Digitalized opportunity space and managerial archetypes: An opportunity-centric perspective on digital innovation and transformation. Organizational Dynamics, 54(1), 101075. https://doi.org/10.1016/j.orgdyn.2024.101075
Ibrahim, A. A., Akindele, M. O., Ganiyu, S. O., Kaka, B., Abdullahi, B. B., Sulaiman, S. K., & Fatoye, F. (2020). The Hausa 12-item short-form health survey (SF-12): Translation, cross-cultural adaptation and validation in mixed urban and rural Nigerian populations with chronic low back pain. PLoS One, 15(5), e0232223. https://doi.org/10.1371/journal.pone.0232223
Isenberg, D. (2010). The Big Idea: How to Start an Entrepreneurial Revolution. Harvard Business Review. https://hbr.org/2010/06/the-big-idea-how-to-start-an-entrepreneurial-revolution?utm_source=chatgpt.com
Isenberg, D. (2011). Introducing the Entrepreneurship Ecosystem: Four Defining Characteristics. Forbes. https://www.forbes.com/sites/danisenberg/2011/05/25/introducing-the-entrepreneurship-ecosystem-four-defining-characteristics/
Karki, Y. (2025). Digitalization and Sustainable Development in the context of Digital Social Enterprises: An Affordance-based Institutional Logics Perspective. https://hdl.handle.net/11250/3214373
Kauffman, Marion, & Foundation. (2019). What are Entrepreneurial Ecosystems? [Blog]. What Are Entrepreneurial Ecosystems? https://www.kauffman.org/ecosystem-playbook-draft-3/ecosystems/
Korhonen, J., Nuur, C., Feldmann, A., & Birkie, S. E. (2018). Circular economy as an essentially contested concept. Journal of cleaner production, 175, 544-552. https://doi.org/10.1016/j.jclepro.2017.12.111
Kreuzer, A., Mengede, K., Oppermann, A., & Regh, M. (2018). Guide for mapping the entrepreneurial ecosystem. Bonn: Deutsche Gesellschaft Für Internationale Zusammenarbeit.
Lamotte, O. (2025). Close but not nearby? Rethinking proximity in the digital era of entrepreneurial ecosystems. Journal of Business Venturing Insights, 23, e00521. https://doi.org/10.1016/j.jbvi.2025.e00521
Lee, G. (2006). The effectiveness of international knowledge spillover channels. European Economic Review, 50(8), 2075–2088. https://doi.org/10.1016/j.euroecorev.2005.10.001
Lee, S. (2025). Designing for the future: how LEED and SDGs drive sustainable art museum architecture. Open House International. https://doi.org/10.1108/OHI-11-2024-0345
Leydesdorff, L., & Meyer, M. (2003). The Triple Helix of university-industry-government relations. Scientometrics, 58(2), 191–203. https://doi.org/10.1023/A:1026276308287
Maier, C., Thatcher, J. B., Grover, V., & Dwivedi, Y. K. (2023). Cross-sectional research: A critical perspective, use cases, and recommendations for IS research. International Journal of Information Management, 70, 102625. https://doi.org/10.1016/j.ijinfomgt.2023.102625
Mason, C., & Brown, R. (2014). Entrepreneurial ecosystems and growth oriented entrepreneurship. Final Report to OECD, Paris, 30(1), 77–102.
Medfouni, H., Mekarssi, L., & Djeffal, K. (2024). A review of the literature on digital entrepreneurship. International Journal of Professional Business Review: Int. J. Prof. Bus. Rev., 9(11), 3. https://dialnet.unirioja.es/servlet/articulo?codigo=9825232
MSCI. (2025). Women on Boards and Beyond: 2024.
Muldoon, J., Liguori, E. W., Solomon, S., & Bendickson, J. (2023). Technological innovation and the expansion of entrepreneurship ecosystems. Review of Managerial Science, 17(5), 1789-1808. https://doi.org/10.1007/s11846-022-00573-1
Muro, M., & Katz, B. (2011). The new “cluster moment”: How regional innovation clusters can foster the next economy. In Entrepreneurship and global competitiveness in regional economies: determinants and policy implications (Vol. 22, pp. 93-140). Emerald Group Publishing Limited. https://doi.org/10.1108/S1048-4736(2011)0000022008
National League of Cities. (2021). National League of Cities. National League of Cities.
Nicole, Loumeau & Peter, Egger. (2019, January 16). The economic geography of innovation. CEPR. http://cepr.org/voxeu/columns/economic-geography-innovation
OECD. (2017). Release of Main Science and Technology Indicators—Latest estimates of R&D investment in OECD and major economies.
Ofem, B., Uzuegbunam, I., & Nambisan, S. (2025). The Interdependence Between Donors and Investors: Liability of Hybridity, Entrepreneurial Ecosystem Affordances, and Venture Financing. Entrepreneurship Theory and Practice, 10422587251347059. https://doi.org/10.1177/10422587251347059
Olutuase, S. O., Brijlal, P., Yan, B., & Ologundudu, E. (2018). Entrepreneurial orientation and intention: Impact of entrepreneurial ecosystem factors. Journal of Entrepreneurship Education, 21(3), 1–14.
Østergaard, C. R., Timmermans, B., & Kristinsson, K. (2011). Does a different view create something new? The effect of employee diversity on innovation. Research Policy, 40(3), 500–509. https://doi.org/10.1016/j.respol.2010.11.004
Özdoğan, B., Dirik, D., & Kahraman, A. (2025). The role of the city in the innovative software entrepreneurship ecosystem: A qualitative study. Journal of Global Entrepreneurship Research, 15(1), 8. https://doi.org/10.1007/s40497-025-00424-9
Polo, A., Morillo-Torres, D., & Escobar, J. W. (2025). Toward Adaptive and Immune-Inspired Viable Supply Chains: A PRISMA Systematic Review of Mathematical Modeling Trends. Mathematics, 13(14), 2225. https://doi.org/10.3390/math13142225
Porter, M. E., & Heppelmann, J. E. (2014). How smart, connected products are transforming competition. Harvard Business Review, 92(11), 64–88. https://moodle2.units.it/pluginfile.php/727297/mod_resource/content/1/How-smart-connected-products-are-transforming-competition.pdf
Rosanna, & Safaya. (2025, June 13). Economic Mobility: How Cities Can Support Entrepreneurs Earning Less Than 100K. National League of Cities. https://www.nlc.org/article/2025/06/13/economic-mobility-how-cities-can-support-entrepreneurs-earning-less-than-100k/
Sba. (2025, August 14). Regional Innovation Clusters | U.S. Small Business Administration. https://www.sba.gov/local-assistance/regional-innovation-clusters
Spigel, B. (2017). The relational organization of entrepreneurial ecosystems. Entrepreneurship theory and practice, 41(1), 49-72. https://doi.org/10.1111/etap.12167
Stam, E. (2015). Entrepreneurial ecosystems and regional policy: A sympathetic critique. European Planning Studies, 23(9), 1759–1769. https://doi.org/10.1080/09654313.2015.1061484
Stam, E., & Van de Ven, A. (2021). Entrepreneurial ecosystem elements. Small Business Economics, 56(2), 809–832. https://doi.org/10.1007/s11187-019-00270-6
Sussan, F., & Acs, Z. J. (2017). The digital entrepreneurial ecosystem. Small Business Economics, 49(1), 55–73. https://doi.org/10.1007/s11187-017-9867-5
Taich, C., Piazza, M., Carter, K., & Wilcox, A. (2016). Measuring Entrepreneurial Ecosystems.
Thukral, M. J. (2025). The Impact of Entrepreneurship on the Resilience of Remote Rural Communities: Transforming Challenges Into Opportunities. Entrepreneurial Opportunities in Disadvantaged Rural Communities, 327–354. https://doi.org/10.4018/979-8-3373-0214-0.ch011
Tomeka. (2025, May 1). How Cities Can Spark Economic Transformation through Entrepreneur-Led Economic Development. National League of Cities. https://www.nlc.org/article/2025/05/01/how-cities-can-spark-economic-transformation-through-entrepreneur-led-economic-development/
Torres, P., & Godinho, P. (2022). Levels of necessity of entrepreneurial ecosystems elements. Small Business Economics, 59(1), 29–45. https://doi.org/10.1007/s11187-021-00515-3
Tran, D.-H., Waheed, N., Saputra, Y. M., Lin, X., Nguyen, C. T., Abdu, T. S., Vo, V. N., Pham, V.-Q., Alsenwi, M., & Adam, A. B. M. (2025). Network Digital Twin for 6G and Beyond: An End-to-End View Across Multi-Domain Network Ecosystems. IEEE Open Journal of the Communications Society.
wainova. (2025, May 14). Startup Policy Ranking Supports Economic Growth and Innovation. WAINOVA. https://wainova.org/startup-policy-ranking-supports-economic-growth-and-innovation/
Wolff, A. W., & Wessner, C. W. (2012). Rising to the challenge: US innovation policy for the global economy.
Zadegan, M. G., Ghazinoory, S., & Nasri, S. (2025). The Triple Helix Model of Innovation and Sustainable Development Goals: A Literature Review. Sustainable Development. https://doi.org/10.1002/sd.70041
Zhang, G., Yang, Y., & Yang, G. (2023). Smart supply chain management in Industry 4.0: The review, research agenda and strategies in North America. Annals of Operations Research, 322(2), 1075–1117. https://doi.org/10.1007/s10479-022-04689-1